V1-X™ High-Yield Microbial Protein Expression

V1-X™ High-Yield Microbial Protein Expression

Twice as fast. Up to sixty times the yield as E. coli.

Twice as fast. Up to sixty times the yield as E. coli.

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Introduction

V1-X™ leverages the fast-growing marine bacterium Vibrio natriegens to outperform traditional E. coli systems. With ~14-minute doubling, tight IPTG control, and up to 60× more soluble protein on difficult targets, V1-X™ is a new workhorse for cytoplasmic, membrane-bound, and secreted expression.

Key Features

Fast
Doubles in ~14 minutes (vs. ~30 min for E. coli)
High Yield
Up to 60× more protein expression for hard targets
Scalable
Works from high-throughput screens to large-volume prep
Flexible
Compatible with pet vectors, 25–37°C conditions
Easy
Safe (BSL1), compatible with standard workflows
Cleaner
Up to 100× lower endotoxins than E. coli

Applications

Strain Engineering

Exploit rapid doubling and high transformation efficiency to accelerate strain construction and pathway optimization—ideal for faster design–build–test cycles without sacrificing yield or stability.

Gene Therapy Vectors

Build and test high-quality vectors quickly. V1-X™ supports large-scale plasmid production with high yield and purity, reducing downstream processing and enabling more iterations in less time.

DNA & Protein Expression

Produce exceptional titers for tough targets, including membrane proteins and toxic constructs. V1-X™’s engineered physiology and growth kinetics shorten fermentation runs and improve reproducibility.

Specifications

Launching in 2026

Sign up to be first to access V1-X™—our next-gen expression strain delivering ~2× growth speed and up to 60× yield.